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Cellular Proliferation and Tissue Development IGF-1 LR3 functions as a potent stimulus for cellular proliferation across multiple tissue types through its activation of IGF-1 receptors and downstream signaling pathways

IGF-I/IGF-IR signaling in osteoclasts Studies of global IGF-I KO mice showed fewer (76% of WT control) and smaller osteoclasts with fewer nuclei in the bone (65), indicating impaired osteoclastogenesis and bone resorption (Figure 2)

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