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Step 3: Cytokine Reduction The downstream result is measurable

doi:10.1016/j.ejmech.2016.10.044 29

15 The SFRP2/DPP4 fibroblast subpopulation serves as the progenitor for fibrogenic fibroblasts in SSc skin, and DPP4-induced NF-kB and SMAD signaling via PAR2 activation leads to dermal fibroblast activation