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A decrease in red blood cell concentration (reflected in the hematocrit) will cause whole blood concentration to fall without a change in pharmacologically active concentrations

However, it's wise to avoid any with exfoliating acids like alpha-hydroxy acids (AHAs), beta-hydroxy acids (BHAs), benzoyl peroxide, or high-strength vitamin C

CagriSema (cagrilintide + semaglutide) is investigational and not approved by any regulator as of mid-2026

The deficiency needs to be corrected through supplementation that bypasses the damaged absorption pathway, while the underlying gut or pancreatic condition is treated separately