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Epithalon is considered one most promising synthetic tetrapeptide compounds in current longevity research, largely due to its proposed mechanism of telomerase activation in aging cell populations

This breakthrough has been supported by the Ministry of Science and ICT through KISTs major project initiatives and the Excellent Young Researcher Program

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Given that for GSH the strongest interactions are formed by the C-terminus of the ECG tripeptide, the binding of CG is not unexpected, the preference for GSH, however, confirms that additional binding energy is contributed by residue E, although its side chain can assume multiple conformations (Fig