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The chemical concentration and treatment duration for each assay were set in accordance with the protocols used in our previously published studies 17,18,19 or pilot studies

In VESPER-2 (weekly dosing in adults with obesity/overweight and type 2 diabetes), Pfizer reported dose-dependent reductions in body weight and HbA1c, including a 2.2% HbA1c reduction at week 28 with 1.6 mg weekly berobenatide (on-treatment estimand) versus 0.2% with placebo

The authors note that they determined depression based on a claims data algorithm

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