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Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y., Aoi, W., Nakajima, A

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The key anti-inflammatory effects included: Modulation of macrophage activation states Decreased reactive nitrogen species production Reduced efferocytotic activity in treated cells Lower expression of pro-inflammatory mediators Research on corneal injuries found TB-500 suppressed multiple inflammatory mediators while maintaining bacterial clearance when combined with antibiotics