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Although our previous research has explored the preliminary mechanisms of EA in the hypothalamus SIRT1-mediated homeostatic feeding and the NTS GLP1 -mediated reward feeding [29, 30], the specificity related to the functional connectivity between neural nuclei and the EA effect has not been deeply probed

* Correspondence: Marco de Scordilli, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Additionally, direct neuronglia communication is facilitated through two-way calcium signaling, primarily via purinergic P2 receptors (notably P2X7) and gap junctions (39)

At 20 mg/mL it is 75 units in a single draw