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It has resulted in the proposal of the Glutathione Deficiency Hypothesis , which suggests that glutathione deficiency is a primary cause of biological aging

It serves as the primary intracellular reducing agent for reactive oxygen species (ROS), a cofactor for glutathione peroxidase (GPx), and a central mediator of hepatic detoxification via glutathione Stransferase (GST) and the glutamyl cycle

Furthermore, the relevance of a Grx(SSR) intermediate and an attack by GSH at the glutaredoxin sulfur atom according to monothiol mechanism (i) were postulated for the reduction of the non-glutathione disulfide bond of the HMA4 domain 60

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