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[14] initially tested the roles of NNMT in gluconeogenesis and found that NNMT knockdown decreases hepatocyte glucose output, glucose-6-phosphatase catalytic (G6pc) expression, and phosphoenolpyruvate carboxykinase 1 cytosolic ( Pck1 ) expression in primary hepatocytes

What exists is mechanistic plausibility, preclinical animal data, and observational reports from research settings

Some people experience side effects like dizziness, irregular periods or breast tenderness

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