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Adverse effects vary by molecule, dose, and patient sensitivity

These skin findings were found more frequently in males (odds ratio [OR], 2.44), older individuals, White individuals, and carriers of MLH1 or MSH2 / EPCAM pathogenic variants

They found that the apparent affinity of the substrate in ASCT1 is 25 times higher than that in ASCT2 in HEK-293 cells

The final section of this review synthesizes these insights into a forward-looking perspective on the future of peptide therapeutics and articulates why the rediscovery of dormant biology, when guided by modern pharmacologic principles, may represent the most productive frontier in drug discovery