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42 found that metabolites in rat urine after the administration of acteoside, such as hydroxytyrosol, 3-hydroxyphenylpropionic acid, and caffeic acid, exhibited higher hepatoprotective activities by regulating oxidative stress, lipid peroxidation, and inflammatory responses in a GalN/LPS-induced acute hepatic injury mouse model than native acteoside

B.YassourM.SaukJ.GarnerA.JiangX.ArthurT.et al

Further investigations have identified a novel compound, tetrahydrofuran (THF), as a key player indicating the effective PL inhibitor