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In addition, the severity of selenium insufficiency may be associated with a higher risk of death in critically sick patients

If topical treatments do not work, certain noninvasive skin procedures, such as laser therapy, may help reduce the appearance of dark eye circles

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Recent studies have shown that melatonin reduces diabetic kidney injury and exerts neuroprotective effects by activating the Nrf2/HO-1 pathway and increasing the levels of antioxidant enzymes HO-1 and NAD(P)H dehydrogenase [quinone] 1 (NQO1) [109, 110]