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Rare but serious effects include pancreatitis, gallbladder disease, and, in rodents, C-cell hyperplasia
Further to this, early preclinical work with dual GIP/GLP-2 hybrid analogues demonstrates considerable therapeutic promise
Conclusions: GLP-1 receptor agonists combined with metformin appear to be the most effective pharmacologic therapies for anthropometric improvement, specifically body weight and BMI reduction, in women with PCOS
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