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Label your vials clearly After reconstitution, label each vial with the date of reconstitution, the concentration (mg/mL), and the discard date (28-30 days post-reconstitution)

Constipation was assessed by frequency of defecation, response to laxatives and feces forms which were classified according to Bristol stool scale, (type 1 = separate hard lumps) (type 2 = sausage shaped and lumpy) (type3 = sausage shaped with cracks on its surface) (type 4 = sausage or snake with smooth surface) (type 5 = soft blobs) (type 6 = fluffy pieces) (type 7 = entirely liquid) 17

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