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MRL /lpr mice (n = 6) were treated with DMSO (0.1 ml 10%), LPX-1(10 mg/kg) or CTX (20 mg/kg) every other day at week 12 for 6 weeks, DMSO (0.1 ml 10%) was applied to sex-matched MRL/Mpj mice (n = 5) as control

Administer REPATHA subcutaneously into areas of the abdomen, thigh, or upper arm that are not tender, bruised, red, or indurated

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Melanocortin Receptor Subtype Activity MT-2 engages melanocortin receptors across four subtypes with varying affinity: MC1R (melanocytes eumelanin synthesis), MC3R (hypothalamus and peripheral tissues energy homeostasis), MC4R (hypothalamus and limbic system appetite, arousal, autonomic function), and MC5R (exocrine glands secretory functions)