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Central region also contains a serine/threonine-rich domain which upon phosphorylation influences the SRC activity

Interestingly, a selective upregulation of the bitter TR TR2R138 was shown in the colon of mice fed a high fat diet (31), and T2R38, a human receptor activated by the same ligand, phenylthiocarbaminde, has been demonstrated not only to be expressed in EEC of the colonic mucosa but also to be induced in overweight/obese subjects (32)

What makes this more important is the two-way relationship between the thyroid and the liver

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