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In SURPASS-2, tirzepatide caused diarrhea in 13-16% of participants, while semaglutide 1 mg caused it in 12%

VLDL Remnants) (6,7) The removal of triglycerides from VLDL by muscle and adipose tissue results in the formation of IDL particles which are enriched in cholesterol

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It has been demonstrated that in animals with ALDH4A1 mutation, vitamin E and vitamin C supplementation can reverse the inhibition of ATPase activity by hyperprolinemia, and appropriate use of antioxidants can also be helpful to reduce neurotoxicity [19]