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Excess food intake or rapid gastric emptying that exceeds the absorptive capacity of the upper small intestine increases the amount of unabsorbed nutrients in the lumen of the more distally located small intestine, thereby increasing the amount of GLP-1 secretion

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Since for some, the current DE was not the first DE in their life, they had chronic extrapyramidal disorders (tremor or akinesia rigidity syndrome) of both drug and subcortical vascular origin, preceding the exacerbation of depression