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Ginsenoside Rg1 (Rg1), a natural compound with limited bioavailability, has demonstrated its efficacy in reducing colonic injury and inflammation, as well as balancing the gut microbiota structure and regulating tryptophan metabolism in DSS-induced UC mice [255]

Maintenance sessions may be advised every few months

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Evening administration faces three obstacles: circadian suppression of autophagy (PER2 gene expression peaks in the evening and actively inhibits autophagy initiation), postprandial insulin signaling (which blocks AMPK-mediated autophagy), and reduced lymphatic clearance during sedentary evening hours