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conducted a randomized, double-blind, placebo-controlled design, it was observed that the combination therapy of pioglitazone and metformin led to a reduction in the concentrations of citrulline and arginine (Irving et al., 2015)

When expressed as percent changes from baseline, the NL treatment group had higher vitamin A levels after 2 hours, while the L treatment showed a progressive increase over time, peaking at 6 hours

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