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Semaglutide targets GLP-1 receptors exclusively, while tirzepatide works on both GLP-1 and GIP (gastric inhibitory polypeptide) receptors

Patients typically begin at a lower dose and increase gradually every four weeks to minimize gastrointestinal side effects and maximize tolerability

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Another possibility is that oxPTM of collagen II and other types of collagens are involved in the development of chronic diabetic complications by eliciting autoimmune responses to target tissues