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Technically, when the FDA first yanked tirzepatide off its shortage list in October 2024, both 503As and 503Bs could no longer legally make copycats (with one notable exception for the smaller 503As, who could still fill individual prescriptions if there was a medical reason the patient needed a slightly different version than the brand-name drugmore on this later)

Abbreviations AC Adenylate cyclase ATP Denosine triphosphate BAT Brown adipose tissue BCAAs Branched-chain amino acids BCKA Branched-chain keto acids BMI Body mass index cAMP Cyclic adenosine monophosphate CNS Central nervous system CREB CAMP response element-binding DIO Diet-induced obesity DPP- 4 Dipeptidyl peptidase- 4 EGFR Epidermal growth factor receptor EPACs Exchange proteins directly activated by Camp Foxo1 Nuclear transcription factor GIP Glucose-dependent insulinotropic polypeptide GIPRAb GIP receptor antagonist antibody GPCRs G-protein-coupled receptors GTP Guanine triphosphate HbA1c Glycated haemoglobin HSL Hormone-sensitive lipase ICV Intracerebroventricular IR Insulin resistance LAGIPRA Long-acting GIP receptor agonist MAPK Mitogen activated protein kinase MASLD Metabolically associated steatotic liver disease PI3 K-PKB/Akt Phosphoinositide- 3-kinaseprotein kinase B/Akt PKA Protein kinase A SUR1 Sulfonylurea receptor 1 T2DM Type 2 diabetes mellitus TORCs Transducers of regulated CREB protein activity ZDF Zucker diabetic fatty Author Contributions ''I.A.A

Visceral fat is strongly associated with increased cardiovascular disease risk, and its reduction typically correlates with improved cardiovascular health markers