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If GLP-1 receptor agonism, and by extension the dual and triple agonists, and possibly the cleaner endogenous peptides like BRP, operates as a class of geroscience interventions rather than a class of weight-loss drugs that happen to have nice cardiovascular side benefits, then the population for whom these molecules might matter is much larger than the population that currently qualifies for them under any obesity- or diabetes-based prescribing guideline

(Table 12)

The decrease in reaction rate is caused by the decrease in [SAM] and the increase in [SAH], which inhibits DNMT

You Have a High BMI (Obesity Class II or III): If you have a significant amount of weight to lose (50+ lbs), the extra potency of Tirzepatide makes a huge difference