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While polymeric nanoparticles have confirmed significant promise, it is essential to compare their performance with other nanoparticle platforms, such as lipid-based, inorganic, and virus-like particles [122]

(ii) Stratification and Long-term Follow-up of Maternal-Fetal Outcomes: Short-term outcomes (miscarriage, preterm birth, structural malformations, placental complications, fetal growth abnormalities) and mid-to-long-term outcomes (offspring growth trajectories, metabolic phenotypes) must be pre-defined within a standardized follow-up framework to assess potential metabolic programming risks

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