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Different mechanisms, different costs, different evidence bases

Short-term safety considerations for initiating therapy: screen for pancreatitis risk, history of gallbladder disease, and current glucose-lowering regimens for semaglutide

Cellular senescence is characterized by a stable arrest in the cell cycle and encompasses a range of cellular changes that culminate in the development of a complex, pro-inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP), which plays a critical role in fibrosis and tumors by affecting numerous processes, including invasion and therapy resistance 10

Adv Neurobiol 24:587600