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For instance, leptin, an anorexigenic hormone, is known to suppress sweet taste sensitivity

The following is one example of a titration schedule used in Phase 2 protocols it does not represent a single universal regimen, and other escalation speeds were also evaluated: Weeks 14: 2 mg once weekly (initiation dose) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Week 13 onwards: 12 mg once weekly (where tolerated) This gradual up-titration mirrors the approach used with approved agents such as semaglutide and tirzepatide, where slow dose escalation is essential to improve gastrointestinal tolerability

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