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The histopathology of cirrhosis shows extensive necrosis of hepatocytes, nodular regeneration of residual hepatocytes, connective tissue hyperplasia, and fibrous septum formation, resulting in the destruction of the liver lobule structure and formation of pseudolobules ( The anti-inflammatory effect of caffeine varies with the treatment protocols and doses ( In the early stage of liver cirrhosis, there are no obvious symptoms due to the strong liver compensatory function, while in the later stage, liver function damage and portal hypertension are the main manifestations, and multiple systems are involved

De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders

28 In fish, Foxl2 was implied to determine and maintain ovarian development via estrogen synthesis