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In fact, NRF2 activation as a clinical target is well established for the treatment of MS since the potent NRF2-activator dimethyl fumarate (DMF) was approved by FDA as first disease-modifying agent in 2013 (Rosito et al., 2020), and by increasing mitochondrial function ( NRF2 in Amyotrophic Lateral Sclerosis ALS is the most common motor neuron disease in adults and estimates have reported that 31,000 patients live with ALS in the US, where on average 5,000 new patients are diagnosed annually (Taylor et al., 2016)

Inhibicin de la melanina: convierte la eumelanina (pigmento oscuro) en feomelanina (pigmento claro), lo que da como resultado un aclaramiento y una luminosidad visibles de la piel

There is also an interesting metabolic connection

*Correspondence: Haddad A