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It acts like natural hormones that control hunger and insulin release

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in Endocrine Reviews : Even a small decrease in cellular ATP concentration results in a major reduction in the transport of T4 (and rT3) but only slightly affects T3 uptake. This makes it inappropriate to use T4-only preparations when treating any condition associated with reduced mitochondrial function or ATP production, Thus, it is not surprising that T3 has been shown to be superior in such patient populations

Stress can lead to emotional eating as a coping mechanism, often resulting in consuming high-calorie foods and hindering weight loss progress