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The most likely 'why' for these positive reports circles right back to the gut-skin axis and systemic inflammation reduction

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A solution to induce an acute hepatic toxicity and a rapidly progressing encephalopathy with severe seizures in rats may be a single paracetamol overdose (5 g/kg intraperitoneally) that excided the regimens previously used (1, 2, 6, 11)

Docetaxel/androgen deprivation therapy (ADT) combined with 150 mg/day of lycopene resulted in dose-limiting toxicity in 1 of 12 cases, establishing it as the MTD