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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases

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Risks of Switching From Semaglutide to Tirzepatide Adverse Effects : Both medications may have commonly reported side effects which are generally gastrointestinal disturbances (nausea, vomiting, diarrhea, stomach upset) and injection-site reactions (1,2,4,5)

Staying physically active, even walking 20 to 30 minutes daily, stimulates gut motility and counteracts semaglutide constipation effect