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Improvement with progesterone withdrawal or suppression: Resolution or marked improvement of symptoms after: Stopping progesterone containing medications Suppressing ovulation (and therefore progesterone production) This response strongly supports progesterone hypersensitivity

12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones

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That's better than nothing, but it's not the same as Phase 2 safety data