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In the human body, the major intracellular derivative of thiamine is its diphosphorylated form, thiamine diphosphate (ThDP)

According to Mankin et al, the rigorousness of the OA destruction was categorized using the histologic standards (Table 2) based on structural variations (scale range 06), cellular variations (scale range 03), damage of safranin O staining (scale range 04) and tidemark integrity (scale range 01) by 3 independent researchers

Trends Pharmacol Sci 30(6):303312 Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E (2012) Efficacy and safety of vismodegib in advanced basal-cell carcinoma

Disagreements about the inclusion/exclusion of studies were discussed and consensus achieved