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Research indicates that the DHODH pathway can protect cells from oxidative stress and mitochondrial damage through various mechanisms, including downregulating ROS levels, maintaining mitochondrial membrane potential, and inhibiting cell apoptosis (77, 78)

Rinse with 3 mL of 10 mmol/L hydrochloric acid aqueous solution and discard the rinse solution

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The Nrf2 pathway is the master regulator of cellular antioxidant and detoxification responses, making it a prime target for bolstering endogenous protection against oxidative stress in MIRI