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Stimulator of interferon genes (STING) proteins can directly bind to and inhibit HK2 while promoting mitochondrial FAO, thus achieving a synergistic effect of metabolic reprogramming and anti-inflammation (83)

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For LTP, repetitive and strong depolarization of the neurons allows significant influx of Ca 2+ into the cytoplasm and activation of protein kinases, including the calcium/calmodulin-dependent protein kinase II (CaMKII), which (a) phosphorylate and activate AMPA-Rs and (b) trigger the insertion of additional AMPA-Rs into the postsynaptic membrane [35]