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1A) had been reported to potentiate GLP-1R-mediated cAMP signaling in response to weak peptidic agonists, including the GLP-1 metabolite GLP-1(936)amide ( 21 ) and the GLP-1R/glucagon-receptor dual agonist oxyntomodulin ( 22 )

35,37 The disease can widely affect multiple systems, including cardiovascular, nervous, and skeletal systems

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While the pill forms of GLP-1 drugs appear to be somewhat less potent, they are likely more convenient to take, which could substantially broaden the use of GLP-1s for weight loss