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At a concentration of 10 mM, exposure was found to cause profound intracellular Ca 2+ overload and significant Ca 2+ -dependent lytic cell death

This will help you understand why digestive side effects like diarrhea can happen when you take this medication

Safety Advantage: Semaglutide The risk of serious side effects from GLP-1 receptor agonists is relatively low, but common side effects like nausea, indigestion, and other forms of GI upset can be expected by most users.6 These digestive issues tend to fade as your body adjusts to the medication and you make lifestyle adjustments based on how the medication affects your metabolism