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Animal model studies consistently demonstrated that semaglutide can significantly alter gut microbiota, suggesting that part of semaglutides metabolic benefit may derive from its capacity to modulate inflammation via gut-immune-microbiota interactions and to correct dysbiosis induced by high-fat diets [82, 84]

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Food and Drug Administration also says in its safety profiles of these drugs that they should not be taken during pregnancy, noting there is "insufficient data" available

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