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It should be noted that the musculoskeletal evidence base remains preclinical, a 2025 scoping review by McGuire and colleagues in Current Reviews in Musculoskeletal Medicine found no adequately powered randomised controlled trials

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Before taking this medicine You should not use Vitamin B12 if you are allergic to cyanocobalamin or cobalt, or if you have Leber's disease (an inherited form of vision loss)

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