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Notably, lactylation also acts as a key mediator for some drugs in cerebral IRI protection, such as Buyang Huanwu Decoction, which effectively inhibits cerebral IRI deterioration by suppressing extensive lysine lactylation and specific H3K18 lactylation [117]

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Sp treatment considerably reduced ROS and promoted higher cell survivability in BSO treated cells, in presence or absence of 3-AT, mainly by maintaining the availability of reduced glutathione (Fig

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