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They used the MADRS depression rating scale, which rates 0 to 6 as normal, no depression, 7 to 19 mild depression, and 20 to 34 moderate depression

PMID: 16798871, PMCID: PMC1839969, DOI: 10.1136/oem.2006.026823

If response seems inadequate after 4-6 months despite good compliance, consider protocol modifications including combination strategies with complementary peptides or topical additions