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Also, utilizing a geranylgeranyl transferase inhibitor (GGTI-289) and farnesyltransferase inhibitor (FTI-227), GGTI-289 but not FTI-227 imitates the impact of simvastatin, recommending that hindrance of geranylgeranylation protein dictates the decreased differentiation of T helper17 cells and the expanded differentiation of Treg cells [65]