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Hu B, Cui R, Li J, Wei H, Zhao J, Bai F, Song W, Ding X (2013) Occurrence and distribution of heavy metals in surface sediments of the Changhua river estuary and adjacent shelf (Hainan Island)

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Additionally, the inhibition of mitochondrial respiration can decrease the transmembrane potential, leading to the release of cytochrome-c, which interacts with the cytoplasmic apoptosis activating factor-1 (Apaf-1) and procaspase-9 initiating the apoptotic cascade (Potoka et al., 2002)