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The retinol dehydrogenases that have been shown to be involved in retinaldehyde and retinol interconversions are members of the short-chain dehydrogenase/reductase (SDR) superfamily of enzymes

This suggests that FOXO4-DRI may selectively target and eliminate senescent cells, potentially alleviating some dysfunctions associated with aged Leydig cells, such as reduced testosterone synthesis

3 Results The groups did not differ at baseline regarding age, sex, BMI, BMI-SDS, pubertal status according to Tanner staging, or glucose tolerance ( Table 1 )