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Correlative analyses in SURV and EPC revealed that IL-12/23p40 is associated with a reduction in multiple Firmicutes species, including Lachnospiraceae , Oscillospiraceae, Eggerthellaceae, and Ruminococcaceae members in nave mice (Additional file 1 Fig

Currently, high-dose subcutaneous semaglutide (2.4 mg once weekly) is approved in the United States and Europe for the treatment of obesity and overweight as an adjunct to a calorie-restricted diet and increased physical activity

Additionally, a meta-analysis of proton magnetic resonance spectroscopy neuroimaging studies found decreased glutamatergic metabolite concentrations in the medial frontal cortex of people with depression compared with healthy people [62]