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Both BPC-157 and TB-500 are classified as research chemicals

Starner RJ, McClelland L, Abdel-Malek Z, Fricke A, Scott G

They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption

Furthermore, it is strongly recommended that patients should strictly adhere to the recommendations of their doctor and be wary of messages communicated by various types of media (including the internet), which often might not stand scientific scrutiny