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Conclusions and future perspective Despite a large part of literature exploring on the accumulation and the origin of ROS, current antioxidant-based therapies lack of specificity for dysfunctional tissues, cells, and organelles, and thus may not reach an effective concentration at the target site of pathologic oxidative stress

In one pivotal trial, participants who received semaglutide injections lost an average of 15% of their body weight over 68 weeks, compared to a 2.4% weight loss in the placebo group

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This occurs when there is limited carbohydrates in the body from diet or starvation and is known as being in a state of ketosis