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6,20 Infants with G6PD deficiency and a mutation of uridine diphosphoglucuronate glucuronosyltransferase-1 gene promoter (UDPGT-1) are particularly susceptible to hyperbilirubinemia secondary to decreased liver clearance of bilirubin

The single feature that most sets MK-677 apart from all of the above is oral activity combined with a long duration of action a once-daily oral compound producing 24-hour effects, versus peptides that are injected and typically shorter-acting

However, no formal research examines this specific application

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