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Although screening studies have demonstrated that additional chemical spaces can modulate epithelial permeability in principle (Lamson et al., 2022), the limited predictive power of simplified in vitro models has further reinforced reliance on well-characterized excipients ( 2.3 Functional excipient combinations Multi-excipient systems can be used to overcome some of these limitations, with several studies showing that combining PEs with complementary co-excipients enhances peptide absorption

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