There is no established direct link between Wegovy and the development of true gastritis (confirmed by endoscopy), but the drug's gastrointestinal side effects are well documented
Understanding why requires appreciating how weight loss itself affects thyroid function: Weight loss reduces leptin levels , which can decrease TRH (thyrotropin-releasing hormone) secretion from the hypothalamus, potentially lowering TSH Improved insulin sensitivity may alter thyroid hormone metabolism and conversion of T4 to T3 Reduced inflammation from fat loss can change the thyroid hormonal milieu Changes in body composition affect thyroid hormone distribution and binding A retrospective study of over 21,000 patients found that hypothyroid individuals using semaglutide experienced modest TSH decreases alongside weight loss
It is a combination of a GLP-1 agonist and an amylin agonist, explains Richard Siegel, MD, co-director of the Diabetes and Lipid Center at Tufts Medical Center and endocrinologist at Tufts Medicine Weight & Wellness Center Stoneham
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